This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands. The multiscale model is tested against published in vitro and in vivo measurements of cell survival with and without boron. The covers that jump out are the ones that get picked up. A total of 48 hemodialysis patients in outpatient clinic were recruited from 2015 to 2017. One third of all human proteins are either transmembrane or soluble secretory proteins that first target the endoplasmic reticulum (ER). On this hub page, you'll find our policies for submitting papers related to COVID-19, as well as content about the outbreak as it appears in Cell Press journals. Hyperleukocytosis and Leukostasis in Acute Myeloid Leukemia: Can a Better Understanding of the Underlying Molecular Pathophysiology Lead to Novel Treatments? Cell presents a special collection reflecting on previous Lasker Awards laureates’ contributions to combating infectious disease. Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell (WBC) count of greater than 100,000/µL, a condition that is frequently referred to as hyperleukocytosis. Five studies reanalyzed dried blood spots (DBS) on filter paper cards, and three studies utilized pre-existing results. The statements, opinions and data contained in the journals are solely The advance of high-throughput omics technologies in recent years has gained us significant knowledge about the molecular mechanisms of JIA. During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules. Multiple genetic and biochemical findings indicate that GUN1 is important for protein homeostasis in the chloroplast; however, a clear and unified view of GUN1′s role in the chloroplast is still missing. PXR is involved in pivotal cellular detoxification processes to include the regulation of genes that encode key drug-metabolizing cytochrome-P450 enzymes, oxidative stress response, as well as enzymes that drive steroid and bile acid metabolism. Nominate yourself or a colleague to be featured.

Moreover, PXR itself exerts positive effect on the cell cycle, thereby predisposing tumor cells to unchecked proliferation. We use cookies to help provide and enhance our service and tailor content and ads. Besides a minor proportion of JIA cases as monogenic, most JIA cases are polygenic disease caused by autoimmune mechanisms. Pregnane X receptor (PXR) is a liver-enriched xenobiotic-responsive transcription factor. Although the role of NOTCH signaling has been extensively studied in health and disease, many questions still remain unresolved. Volume 183, Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels. Studies and clinical trials are being performed that focus on the inhibition of metabolic enzymes by small molecules or dietary interventions (e.g., fasting, calorie restriction, and intermittent fasting). We use cookies to help provide and enhance our service and tailor content and ads. There is limited research examining the metabolic imprint of diabetes on newborn screening results. We performed a systematic search of the available literature from 1 April 1998 to 31 December 2018 involving newborn screening and diabetes using OVID, MEDLINE, Cochrane and the PROSPERO register, utilizing a modified extraction tool adapted from Cochrane. Molecular and Cellular Mechanisms of Parkinson's Disease, Anti-Müllerian Hormone Type II Receptor Expression in Endometrial Cancer Tissue, ER-to-Golgi Transport in HeLa Cells Displays High Resilience to Ca. This study aims to examine mutual interaction of various clinical factors for CI in patients receiving hemodialysis. GUN1 (genomes uncoupled 1), a chloroplast-localized pentatricopeptide repeat (PPR) protein with a C-terminal small mutS-related (SMR) domain, plays a central role in the retrograde communication of chloroplasts with the nucleus.

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